Not really.
Most of my reactions are just curiosity (most people just watch, few have ever approached me, and those have generally been limited to comments like "cool drone") smiles, and waves.
I have had several friendly conversations with a security gaurd where I like to fly, he is just interested in the drone and thinks it's cool.
Another gaurd there asked me to fly somewhere else, which of course means nothing (it's public land, as is of course the airspace) but since I was almost done anyway and didn't feel like arguing I just packed up. Closest thing to a negative reaction.
FYI, I have a few other observations:
I have also been known to Open Carry a pistol on occasion (so far I haven't done it while flying yet) either because I legally had to (because I could not legally conceal a pistol in that location but could legally Open Carry one) or as a political statement and I have noted that the majority of people are very unobservant, they don't even seem to notice. Even on the rare occasions that I have been carrying a rifle (protests and pro second amendment rallies at the state capital) in addition to my pistol most people do not notice. I feel like I could almost carry an RPG if I had one and not raise an eyebrow, it really is amazing. It is not my intention to shock, but it is surprising the level of people who just seem completely oblivious to the world around them, which is my point in talking about this. Or if they do notice they simply don't say anything or react in any way.
Most of my reactions (from the oeople who do notice) here too have been positive or just curious as well. I have only had one truly negative reation, a hard lefty woman (who by the way looked the part, complete with the ugly glasses and the "I want to see the manager" haircut) who claimed to be "afraid" (as justification why we should not exercise our rights) yet still marched up to 30 people (men and women by the way) carrying rifles and loudly demanded (in a slew of explatives) that we leave "her" public park. (We were there protesting a wrongful arrest and due process violations of a man (who did not own a car) who was legally transporting a new rifle to a friends house in the only manner he legally could in this state as an 18 year old, openly (a case could potentially be interpreted as concealing by an over zealous cop (the law has a hole in it where a specific transport exception is written for personal vehicles but not foot travel or public transport)), on foot, and his prosecution on ADMITTED false charges, he was later aquitted and went on to sue the city by the way) I also once had a woman ask if my safety was on while I was carrying a Glock, which does not have a manual safety, which I told her, that was the end of that interaction. My oher reactions have all been positve, mostly just comments like "cool" or people wanting to randomly "talk shop," a few have even thanked me for carrying.
I should imagine that the same is somewhat the true for drones, most people don't even notice, and most of the ones that do don't care or just think it's cool. It's only the misinformed or paranoid that seem to have a problem with it.